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\fi-540\li540\ri0\nowidctlpar\faauto\outlinelevel0\rin0\lin540\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 \par }\pard \s1\qc \li0\ri0\nowidctlpar\faauto\outlinelevel0\rin0\lin0\itap0 {\f1\fs20 Epidemiol\'f3gia migr\'e9ny \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf17 Prevalencia : \'9eeny 17,6 -18,2% mu\'9ei 5,7 - 6,5% \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 53% migrenikov - \'faplna pr\'e1ceneschopnos\'9d a k\'beud na l\'f4\'9eku \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 112 mili\'f3 nov dn\'ed na l\'f4\'9eku / rok \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 13 mili\'e1 rd $ / rok (pracovn\'e1 absencia a \par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 zn\'ed\'9een\'e1 produktivita pr\'e1ce) \par \par \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 Epidemiol\'f3gia migr\'e9ny \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf17 30% migrenikov nikdy nenav\'9at\'edvilo lek\'e1ra pre bolesti hlavy \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 40% migrenikov u \'9e\'edva lieky vydan\'e9 na recept \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 58% migrenikov u \'9e\'edva vo\'bene dostupn\'e9 analgetik\'e1 \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 29% migrenikov je spokojn\'fdch s lie\'e8b}{\f1\fs20\cf17 ou \par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 Etiopatogen\'e9za migr\'e9ny \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf17 \par }{\f42\fs20\cf17 N\'e1chylnos\'9d k z\'e1chvatu ( individu\'e1lna reakcia CNS na vyvol\'e1vaj\'face faktory) \par {\pntext\pard\plain\s2 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\pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 porucha mitochondri\'e1lneho metabolizmu \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 n\'ed zka hladina Mg+ \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 porucha kalciov\'fdch kan\'e1lov \par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\b\f1\fs20\cf17 \par }{\f1\fs20\cf17 \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 Migr\'e9na a genetika \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf17 \par {\pntext\pard\plain\s2 \f14\fs54\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs54 {\pntxtb n}}\faauto\ls2\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 g\'e9 ny pre kalciov\'e9 kan\'e1ly (19p13) }{\i\f1\fs20\cf17 famili\'e1rna hemiplegick\'e1 migr\'e9na \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 g\'e9 ny pre seroton\'ednov\'e9 receptorov\'e9 subtyty \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 g\'e9 ny pre dopam\'ednov\'e9 receptory D2 \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 g\'e9 n pre migr\'e9nu viazan\'fd na chromoz\'f3m X \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 mut\'e1 cie mitochondri\'e1lnej DNA \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 Seroton\'ednov\'e9 receptory \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf17 Vaskul\'e1rne : \par \par }{\f42\fs20\cf17 vazodilata\'e8n\'e9: 5-HT2B a 5-HT7 \par }{\f1\fs20\cf17 aktiv\'e1cia trigeminovaskul\'e1rneho \par syst\'e9mu \par rekurentn\'e1 vazodilat\'e1cla po \par podan\'ed triptanov \par \par }{\f42\fs20\cf17 vazokonstrik\'e8n\'e9: 5-HT1B \par }{\f1\fs20\cf17 normaliz\'e1cia cievnej steny \par \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 Seroton\'ednov\'e9 receptory \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf17 Neuron\'e1lne: \par \par }{\f42\fs20\cf17 5-HT1D : inhib\'edcia uvo\'benenia vazoakt\'edvnych \par }{\f1\fs20\cf17 neurotransmiterov, inhib\'edcia nausey \par a vracania \par \par }{\f42\fs20\cf17 5-HT1F: inhib\'edcia uvo\'benenia vazoakt\'edvnych \par }{\f1\fs20\cf17 neurotransmiterov \par normaliz\'e1cia cievnej steny \par \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 Patofyziol\'f3gia migr\'e9ny \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf17 aktiv\'e1cia \'84migrenick\'e9ho centra\'93 v mozg.kmeni \par }\pard \s2\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin0\itap0 {\f1\fs20\cf17 (ncl. coeruleus + ncl.raphe dorsalis et magnus \par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 + periaquaedukt\'e1lna siv\'e1 hmota) \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 vznik a v\'fdvoj \'9a\'edriacej sa kortik\'e1lnej depresie \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 aktiv\'e1 cia trigeminovaskul\'e1rneho syst\'e9mu \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 prenos bolesti do CNS \par }\pard\plain \s1\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin540\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 \par \par \par }\pard \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 {\f42\fs20 Provoka\'e8n\'e9 faktor}{\f1\fs20 y migr\'e9ny}{\b\f1\fs20 \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20\cf17 Stres: mal\'e9 nedostatky, ve\'bek\'e9 straty, hnev,konflikty \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 Prostredie: v \'f4ne a\~z\'e1pachy, po\'e8asie \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 Hormon\'e1 lne zmeny: menses, menopauza, \par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 p.o. kontracept\'edva, hormon\'e1lna subst.terapia \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 Sp\'e1 nok: nadmern\'fd (po prolongovanom strese), \par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 neadekv\'e1tny \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 Aktivita: nadmern \'e1 fyzick\'e1 aktivita, vyn\'faten\'e1 \par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 poloha \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 Lieky: nitr\'e1 ty, teofyl\'edn, nifedip\'edn, cimetidin\tab \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 Potraviny \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 Klinick\'fd obraz migren\'f3zneho z\'e1chvatu \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f1\fs20\cf17 5 \'9at\'e1di\'ed:}{\f1\fs20\cf17 \par }{\b\f1\fs20\cf17 1. prodr\'f3my : }{\f1\fs20\cf17 poruchy aliment\'e1rne, }{\b\f1\fs20\cf17 }{\f1\fs20\cf17 neurologick\'e9, poruchy pozornosti,emotivity, spr\'e1vania }{\b\f1\fs20\cf17 \par 2. aura : }{\f1\fs20\cf17 senzit\'edvna, senzorick\'e1, motorick\'e1, fatick\'e1}{\b\f1\fs20\cf17 \par }{\b\f42\fs20\cf17 3. boles\'9d hlavy + sprievodn\'e9 pr\'edznaky \par }{\b\f1\fs20\cf17 }{\f1\fs20\cf17 nausea, vracanie, fotof\'f3bia, fonof\'f3bia}{\b\f1\fs20\cf17 \par }{\b\f42\fs20\cf17 4. \'fa\'beava: }{\f42\fs20\cf17 \'fanava, dysf\'f3ria, euf\'f3ria, boles\'9d svalov }{\b\f1\fs20\cf17 \par 5. uzdravenie: }{\f1\fs20\cf17 medzi atakmi pln\'e9 zdravie }{\b\f1\fs20\cf17 \par \par }\pard\plain \s1\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin540\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 \par }\pard \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 {\f1\fs20 IHS diagnostick\'e9 krit\'e9ri\'e1 \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f1\fs20\cf17 1.1 Migr\'e9na bez aury \par 1.2 Migr\'e9na s aurou \par }{\f1\fs20\cf17 1.2.1 Migr\'e9na s typickou aurou \par 1.2.2 Migr\'e9na s prolongovanou aurou \par 1.2.3 Famili\'e1rna hemiplegick\'e1 migr\'e9na \par 1.2.4 Bazil\'e1rna migr\'e9na \par 1.2.5 Migren\'f3zna aura bez bolesti hlavy \par }{\f42\fs20\cf17 1.2.6 Migr\'e9na s n\'e1hlym za\'e8iatkom aury \par }{\b\f1\fs20\cf17 1.3 Oftalmoplegick\'e1 migr\'e9na \par 1.4 Retin\'e1lna migr\'e9na \par }{\b\f42\fs20\cf17 1.5 Periodick\'e9 syndr\'f3my detsk\'e9ho veku, ktor\'e9 m\'f4\'9eu by\'9d \par }{\b\f1\fs20\cf17 prekurzorom migr\'e9ny alebo asociovan\'e9 s migr\'e9nou \par 1.6 Komplik\'e1cie migr\'e9ny \par }{\f1\fs20\cf17 1.6.1 Migren\'f3zny status \par 1.6.2 Migren\'f3zny infarkt \par }{\b\f1\fs20\cf17 1.7 Migren\'f3zne }{\b\f42\fs20\cf17 ochorenie nesp\'e5\'f2aj\'face horeuveden\'e9 krit\'e9ri\'e1}{\f1\fs20\cf17 \par \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 IHS diagnostick\'e9 krit\'e9ri\'e1 \par }\pard\plain \s2\ql \fi-840\li840\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin840\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f1\fs20\cf17 Migr\'e9na bez aury \par }{\b\f42\fs20\cf17 A. Aspo\'f2 5 z\'e1chvatov sp\'e5\'f2aj\'facich B,D \par }{\b\f1\fs20\cf17 B. Z\'e1chvaty bolest\'ed hlavy trvaj\'fa 4-72 h \par }{\b\f42\fs20\cf17 C. Boles\'9d hlavy m\'e1 aspo\'f2 2 z nasleduj\'facich \par }{\b\f1\fs20\cf17 charakterist\'edk: jednostrann\'e1 lokaliz\'e1cia, pulzuj\'faci charakter, stredn\'e1 a\'9e siln\'e1 \par intenzita, zhor\'9aenie pri be\'9enej fyzickej aktivite \par }{\b\f42\fs20\cf17 D. S\'fa\'e8asne s boles\'9dou je pr\'edtomn\'fd aspo\'f2 1 nasleduj\'faci pr\'edznak: nauzea alebo zvracanie, foto alebo fonof\'f3bia \par }{\b\f1\fs20\cf17 \par }{\b\f1\fs20\cf18 }{\f1\fs20\cf17 \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 IHS diagnostick\'e9 krit\'e9ri\'e1 \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f1\fs20\cf17 Migr\'e9na s aurou \par }{\b\f42\fs20\cf17 A. aspo\'f2 2 z\'e1chvaty sp\'e5\'f2aj\'face B \par B. aspo\'f2 3 z nasleduj\'facich 4 charakterist\'edk: \par }{\b\f1\fs20\cf17 1. jeden alebo viac plne reverzibiln\'fdch pr\'edznakov aury \par 2. postupn\'fd v\'fdvoj jedn\'e9ho sympt\'f3mu aury viac ako 4 min, alebo sa objavuj\'fa n\'e1sledne 2 sympt\'f3my \par 3. \'9eiadny sympt\'f3m netrv\'e1 viac ako 60 min \par }{\b\f42\fs20\cf17 4. boles\'9d hlavy nasleduje po vo\'benom intervale \par krat\'9aom ako 60 min ( m\'f4\'9ee za\'e8a\'9d pred alebo \par s\'fa\'e8asne s aurou) \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 Vy\'9aetrovacie met\'f3dy \par {\pntext\pard\plain\s2 \f14\fs54\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs54 {\pntxtb n}}\faauto\ls2\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f1\fs20\cf17 EEG}{\f1\fs20\cf17 : n\'e1lezy nev\'fdznamn\'e9 pre klinick\'fa dg. \par {\pntext\pard\plain\s2 \f14\fs54\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs54 {\pntxtb n}}\faauto\ls2\outlinelevel1\rin0\lin540\itap0 {\b\f1\fs20\cf17 CT}{ \f1\fs20\cf17 : vyl}{\f42\fs20\cf17 \'fa\'e8enie \'9atruktur\'e1lnej l\'e9zie \par {\pntext\pard\plain\s2 \f14\fs54\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs54 {\pntxtb n}}\faauto\ls2\outlinelevel1\rin0\lin540\itap0 {\b\f1\fs20\cf17 MRI}{ \f1\fs20\cf17 : abnormality bielej hmoty (12-47%),atrofia mozgu (68%) \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 Vy\'9aetrenie }{ \b\f1\fs20\cf17 antifosfolipidov\'fdch protil\'e1tok}{\f1\fs20\cf17 : \par }\pard \s2\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin0\itap0 {\f1\fs20\cf17 pozit\'edvne u 0-24% migrenikov, nie s\'fa \par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 rizikov\'fdm faktorom pre NCMP u migrenikov \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 Vy\'9aetrenie }{ \b\f1\fs20\cf17 cerebrospin\'e1lneho likvoru \par }\pard\plain \s1\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin540\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 \par }\pard \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 {\f42\fs20 Lie\'e8ba ak\'fatneho migren\'f3zneho z\'e1chvatu \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f1\fs20\cf17 Ciele:}{\f1\fs20\cf17 \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 r\'fdchlo a \'faplne odstr\'e1ni\'9d sympt\'f3my migr\'e9ny \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 obnovi\'9d pacientovu funk\'e8nos\'9d \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 minimalizova \'9d pou\'9eitie z\'e1chrannej terapie \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 optimal}{ \f42\fs20\cf17 izova\'9d pacientovu schopnos\'9d postara\'9d sa o seba \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 zn\'ed\'9ei\'9d z\'e1vislos\'9d n}{\f1\fs20\cf17 a ambulantnej zdravotnej starostlivosti \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 minimalizova \'9d alebo vyl\'fa\'e8i\'9d ne\'9eiad\'face \'fa\'e8inky \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20 Lie\'e8ba ak\'fatneho migren\'f3zneho z\'e1chvatu \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf17 Strat\'e9gia postupn\'fdch krokov \par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 Triptany \par Opioidy \par Kortikoidy \par Analgetik\'e1 Ergotam\'edny \par NSA 3.krok \par Antiemetik\'e1 2.krok \par \~ 1. krok \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20 Lie\'e8ba ak\'fatneho migren}{\f1\fs20 \'f3zneho z\'e1chvatu \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20\cf17 Stratifika\'e8n\'e1 strat\'e9gia\~ \par \~I.stupe\'f2 : analgetik\'e1 / NSA \'b1 antiemetik\'e1 \par II.stupe\'f2 : analgetik\'e1 /NSA \'b1 antiemetik\'e1 \par }{\f1\fs20\cf17 egotam\'edny + antiemetik\'e1 (i.v.) \par triptany \par }{\f42\fs20\cf17 III.stupe\'f2: antiemetik\'e1 (i.v.) \par }{\f1\fs20\cf17 ergotam\'edny + antiemetik\'e1 (i.v.) \par triptany \par opioidy / kortikosteroidy \par \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20 Lie\'e8ba ak\'fatneho migren\'f3zneho z\'e1chvatu \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f42\fs20\cf17 Stupe\'f2 A: }{\f1\fs20\cf17 nesteroidn\'e9 antireumatik\'e1 a neopi\'e1tov\'e9 analgetik\'e1, intranaz\'e1lny ergotamin, or\'e1lne opioidn\'e9 analgetik\'e1 \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\b\f42\fs20\cf17 Stupe\'f2 B:}{ \f1\fs20\cf17 dihydergotamin, parenter\'e1lne opioidn\'e9 analgetik\'e1, parentenr\'e1lne antiemetik\'e1, lidocain IV,IN \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\b\f42\fs20\cf17 Stupe\'f2 C: } {\f1\fs20\cf17 triptany, ergotamin, or\'e1lne antiemetik\'e1, kortikoidy \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20 Profylaktick\'e1 lie\'e8ba \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f1\fs20\cf17 Je indikovan\'e1, ak pacient }{ \b\f42\fs20\cf17 sp\'e5\'f2a jedno alebo viac z nasleduj\'facich: \par {\pntext\pard\plain\s2 \f14\fs41\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs41 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 opakuj\'fa ce sa z\'e1chvaty interferuj\'face s dennou aktivitou napriek ak\'fatnej lie\'e8be \par {\pntext\pard\plain\s2 \f14\fs41\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs41 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 \'e8ast\'e9 bolesti hlavy \par {\pntext\pard\plain\s2 \f14\fs41\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs41 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 kontraindik\'e1 cia, zlyhanie alebo nadmern\'e9 u\'9e\'edvanie ak\'fatnej lie\'e8by \par {\pntext\pard\plain\s2 \f14\fs41\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs41 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 ne\'9eiad\'face \'fa\'e8inky spojen\'e9 s ak\'fatnou lie\'e8bou \par {\pntext\pard\plain\s2 \f14\fs41\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs41 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 n\'e1klady}{ \f42\fs20\cf17 na ak\'fatnu a prevent\'edvnu lie\'e8bu \par {\pntext\pard\plain\s2 \f14\fs41\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs41 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 pacientove preferencie \par {\pntext\pard\plain\s2 \f14\fs41\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs41 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 komplikovan\'e9 typy migr\'e9ny: hemiplegick\'e1 m., bazil\'e1rna m., m. s prolongovanou aurou, m. infarkt \par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 \par \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20 Profylaktick\'e1 lie\'e8ba \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf17 Ciele: \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 Zn\'ed\'9e enie frekvencie z\'e1chvatov \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 Zn\'ed\'9e enie intenzity z\'e1chvatu \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 Skr\'e1tenie z \'e1chvatu \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 Zv\'fd\'9aenie \'fa\'e8innosti ak\'fatnej lie\'e8by \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 Zlep\'9a enie funk\'e8nosti pacienta \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 Odstr\'e1 nenie pracovnej neschopnosti \par }\pard \s2\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin0\itap0 {\f1\fs20\cf17 \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20 Profylaktick\'e1 lie\'e8ba \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20\cf17 Doplnkov\'e1 a alternat\'edvna lie\'e8ba \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 relaxa\'e8n\'e9 cvi\'e8enia \par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf17 techniky biofeedback : term\'e1lny, EMG, EEG \par kognit\'edvno-behavior\'e1lna terapia \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 alternat\'ed vna lie\'e8ba: akupunkt\'fara, nutri\'e8n\'e1 \par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 lie\'e8ba, Mg+, vitam\'edn B2, rastlinn\'e9 pr\'edpravky \par }{\f1\fs20\cf17 (tenacetum parthenium, guarana, ginkgo , \par valeriana ), aromaterapia (pepermintov\'fd olej), capsaicin i.n. \par {\pntext\pard\plain\s2 \f14\fs48\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs48 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf17 \'9eiadne doporu \'e8enie t\'fdkaj\'face sa: hy}{\f1\fs20\cf17 pn\'f3zy, TENS, cervik\'e1lnej manipul\'e1cie \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20 Profylaktick\'e1 lie\'e8ba \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20\cf17 Krit\'e9ri\'e1 pre porovnanie \'fa\'e8 innosti profylaktickej lie\'e8by \par (doporu\'e8enie US Headache Consortium) \par {\pntext\pard\plain\s2 \f14\fs41\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs41 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\b\f1\fs20\cf17 Skupina 1:}{ \f1\fs20\cf17 divalpro\'e1t sodn\'fd, valpro\'e1t sodn\'fd, amitriptylin, propranolol, timolol \par {\pntext\pard\plain\s2 \f14\fs41\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs41 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\b\f1\fs20\cf17 Skupina 2:}{ \f1\fs20\cf17 atenolol, metoprolol, nadolol, nimodipin, verapamil, k.acetylosalicylov\'e1, ketoprofen, naproxen, fluoxetin, gabapentin, estradiol, magnesium, riboflavin \par {\pntext\pard\plain\s2 \f14\fs41\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs41 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\b\f1\fs20\cf17 Skupina 3:}{ \f1\fs20\cf17 nortriptylin, imipramin, doxepin, paroxetin, sertralin, trazodon, venlafaxin, fluvoxamin, diltiazem, ibuprofen, methylergometrin, tiagabin, topiram\'e1t \par {\pntext\pard\plain\s2 \f14\fs41\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs41 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\b\f1\fs20\cf17 Skupina 4:}{ \f1\fs20\cf17 flunarizin, methysergide,TR-DHE \par {\pntext\pard\plain\s2 \f14\fs41\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs41 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\b\f1\fs20\cf17 Skupina 5:}{ \f1\fs20\cf17 klonidin, karbamazepin, vigabatrin, nifedipin, indomethacin, dihydroergocryptin \par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 Princ\'edpy nasadz}{\f42\fs20 ovania profylaktickej lie\'e8by \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f1\fs20\cf17 Koexistencia chor\'f4b: \par }{\f42\fs20\cf17 A. vybra\'9d liek \'fa\'e8inn\'fd na obidve ochorenia \par B. zabezpe\'e8i\'9d, aby koexistuj\'face ochorenia neboli \par }{\f1\fs20\cf17 kontraindik\'e1ciou pre vybran\'fd profylaktick\'fd liek \par }{\f42\fs20\cf17 C. zabezpe\'e8i\'9d, aby lie\'e8ba pou\'9eit\'e1 pre \par }{\f1\fs20\cf17 koexistuj\'face ochorenie nevyvol\'e1vala \par migr\'e9nu \par }{\f42\fs20\cf17 D. vyl\'fa\'e8i\'9d interakcie medzi liekmi na migr\'e9nu a \par }{\f1\fs20\cf17 liekmi na koexistuj\'face ochorenie \par }{\f42\fs20\cf17 E. venova\'9d pozornos\'9d lie\'e8be \'9eien v gravidite, \par }{\f1\fs20\cf17 alebo s potencion\'e1lnou graviditou \par (teratogenicita) \par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20 Kontraindik\'e1cie profylaktickej lie\'e8by u migrenikov s: \par }\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f1\fs20\cf17 Komorbidita: Vhodn\'fd liek: Kontraindikovan\'fd liek: \par }{\f1\fs20\cf17 Hepatopatia divalpro\'e1t sodn\'fd, NSAID \par Astma\tab Ca-blok\'e1tory \'df-blok\'e1tory \tab \par Kardiovaskul. \'df-blok\'e1tory methysergid, ergotam\'edn\tab \par ochorenia Ca-blok\'e1tory \par NSAID \par Epilepsia\tab divalpro\'e1t sodn\'fd TCA \tab \par Depresia TCA \'df-blok\'e1tory \par DM Ca-blok\'e1tory \'df-blok\'e1tory \par Gravidita nefarmakol. Th divalpro\'e1t sodn\'fd \par }\pard\plain \s1\qc \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20 Z\'e1ver \par {\pntext\pard\plain\s2 \f14\fs54\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs54 {\pntxtb n}}\faauto\ls2\outlinelevel1\rin0\lin540\itap0 \fs56\cf1\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f1\fs20\cf17 kontrola bolesti hlavy neznamen\'e1 trval\'e9 a \'faplne odstr\'e1nenie bolesti \par {\pntext\pard\plain\s2 \f14\fs54\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs54 {\pntxtb n}}\faauto\ls2\outlinelevel1\rin0\lin540\itap0 {\b\f42\fs20\cf17 snaha o zabezpe\'e8enie norm\'e1lneho \'9eivota \par {\pntext\pard\plain\s2 \f14\fs54\cf17 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs54 {\pntxtb n}}\faauto\ls2\outlinelevel1\rin0\lin540\itap0 {\b\f1\fs20\cf17 mo\'9e nosti soci\'e1lneho pl\'e1novania bez strachu z interferencie bolesti hlavy}{\f1\fs20\cf17 \par }}