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{\title Neuromuskul\'e1rne ochorenia}{\author x}{\operator x}{\creatim\yr2007\mo6\dy3\hr22}{\revtim\yr2007\mo6\dy4\hr22\min11}{\printim\yr2007\mo6\dy3\hr21\min59}{\version3}{\edmins2}{\nofpages4}{\nofwords1320}{\nofchars7525}{\*\company x}{\nofcharsws0}
{\vern8249}}\margt709\margb1134 \widowctrl\ftnbj\aenddoc\hyphhotz425\noxlattoyen\expshrtn\noultrlspc\dntblnsbdb\nospaceforul\hyphcaps0\horzdoc\dghspace120\dgvspace120\dghorigin1701\dgvorigin1984\dghshow0\dgvshow3
\jcompress\viewkind1\viewscale100\nolnhtadjtbl \fet0\sectd \linex0\headery708\footery708\colsx708\sectdefaultcl {\*\pnseclvl1\pnucrm\pnstart1\pnindent720\pnhang{\pntxta .}}{\*\pnseclvl2\pnucltr\pnstart1\pnindent720\pnhang{\pntxta .}}{\*\pnseclvl3
\pndec\pnstart1\pnindent720\pnhang{\pntxta .}}{\*\pnseclvl4\pnlcltr\pnstart1\pnindent720\pnhang{\pntxta )}}{\*\pnseclvl5\pndec\pnstart1\pnindent720\pnhang{\pntxtb (}{\pntxta )}}{\*\pnseclvl6\pnlcltr\pnstart1\pnindent720\pnhang{\pntxtb (}{\pntxta )}}
{\*\pnseclvl7\pnlcrm\pnstart1\pnindent720\pnhang{\pntxtb (}{\pntxta )}}{\*\pnseclvl8\pnlcltr\pnstart1\pnindent720\pnhang{\pntxtb (}{\pntxta )}}{\*\pnseclvl9\pnlcrm\pnstart1\pnindent720\pnhang{\pntxtb (}{\pntxta )}}\pard\plain 
\s1\ql \li0\ri0\nowidctlpar\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\fs20 Neuromuskul\'e1rne}{\f34\fs20  ochorenia\line \line pre o\'9aetrovate\'bestvo}{\fs20\cf1 Miroslav Brozman
\par }\pard\plain \s2\ql \li0\ri0\nowidctlpar\faauto\outlinelevel1\rin0\lin0\itap0 \fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Neurologick\'e1 klinika FN Nitra
\par }\pard\plain \s1\ql \li0\ri0\nowidctlpar\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f1\fs20\cf17 Neuromuskul\'e1rne ochorenia  (nervosvalov\'e9)
\par {\pntext\pard\plain\s2 \f14\fs36\cf18 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs36 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f1\fs20\cf18 Anatomick\'e9 delenie: 
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\fs40\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\b\f1\fs20\cf18 Choroby predn\'fdch rohov miechy
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Choroby miechov\'fd}{\b\f42\fs20\cf18 ch kore\'f2ov
\par {\pntext\pard\plain\s4 \f14\fs26\cf18 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs26 {\pntxtb n}}\faauto\ls2\outlinelevel3\rin0\lin1800\itap0 {\b\f1\fs20\cf18 Choroby perif
\'e9rnych nervov
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Ochorenia nervosvalov\'e9ho prenosu
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 ochorenia
\par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Choroby predn\'fdch rohov miechy
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\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Spin\'e1lne svalov\'e9 atrofie}{\f1\fs20\cf1 :
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\fs40\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Ak\'fatna infantiln\'e1 forma (m. Werdnig-Hoffmann)}{\f1\fs20\cf1 :  u\'9e po p\'f4rode, perif\'e9rny hypotonick\'fd syndr\'f3m, bulb\'e1rne poruchy, exitus do 1.r.
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 infantiln\'e1 forma (chronick\'e1)}{\f42\fs20\cf1 :  naj\'e8astej\'9aia, n\'e1padn\'e1 je rastov\'e1 retard\'e1cia dolnej polovice tela, 10 \endash  20 r.
\par {\pntext\pard\plain\s4 \f14\fs26\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs26 {\pntxtb n}}\faauto\ls2\outlinelevel3\rin0\lin1800\itap0 {\f1\fs20\ul\cf1 Juveniln\'e1
 forma (m. Kugelberg-Welander)}{\f42\fs20\cf1 :  v pred\'9akolskom veku, slabos\'9d proxim\'e1lneho svalstva, progresia pomal}{\f1\fs20\cf1 \'e1
\par {\pntext\pard\plain\s4 \f14\fs26\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs26 {\pntxtb n}}\faauto\ls2\outlinelevel3\rin0\lin1800\itap0 {\f1\fs20\ul\cf1 Adultn\'e1
 forma (m. Aran-Duchenne)}{\f42\fs20\cf1 :   vz\'e1cna, za\'e8\'edna spravidla po 30. r., drobn\'e9 svaly r\'fak, nek\'f4r aj n\'f4h
\par {\pntext\pard\plain\s4 \f14\fs26\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs26 {\pntxtb n}}\faauto\ls2\outlinelevel3\rin0\lin1800\itap0 {\f1\fs20\ul\cf1 Bulbospin\'e1
lna forma (m. Kennedy}{\f1\fs20\cf1 ):  viazan\'e1 na X-chromoz\'f3m
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\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20\ul\cf1 S\'fa\'e8asn\'e9 postihnutie centr\'e1lneho a perif\'e9rneho neur\'f3nu}{\f1\fs20\cf1 :
\par {\pntext\pard\plain\s4 \f14\fs26\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs26 {\pntxtb n}}\faauto\ls2\outlinelevel3\rin0\lin1800\itap0 
\fs40\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Amyotrofick\'e1 later\'e1lna skler\'f3za (ALS)}{\f42\fs20\cf1 :  let\'e1lna choroba, etiol\'f3gia nie je zn\'e1ma, medzi 35.-50.r., u mu\'9eov \'e8astej\'9aia, spastick\'e1
 hyperrefle}{\shad\f1\fs20\cf1 xia, }{\f1\fs20\cf1 fascikul\'e1cie, svalov\'e9 atrofie, bulb\'e1rne poruchy, trvanie 2-3 r.}{\f1\fs20\ul\cf1 
\par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Heredit\'e1rne neuropatie
\par {\pntext\pard\plain\s2 \f14\fs30\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs30 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Heredit\'e1rna motoricko-senzit\'edvna neuropatia (HSMN, m. Charcot-Marie-Tooth}{\f1\fs20\cf1 ):  heterog\'e9nna etiol\'f3gia
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\fs40\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20\ul\cf1 Hypertrofick\'e1, demyeliniza\'e8n\'e1 forma (HSMN, typ I.)}{\f1\fs20\cf1  \endash   v detstve, AD - 17.chromoz\'f3m, 1.chrom., X a AR forma
\par {\pntext\pard\plain\s4 \f14\fs26\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs26 {\pntxtb n}}\faauto\ls2\outlinelevel3\rin0\lin1800\itap0 {\f1\fs20\ul\cf1 Neuron\'e1
lna forma (HSMN, typ II.)}{\f1\fs20\cf1  \endash  adolescencia a dospel\'fd vek, chab\'e1 parapar\'e9za s perone\'e1lnymi atrofiami, AD a  AR formy
\par {\pntext\pard\plain\s4 \f14\fs26\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs26 {\pntxtb n}}\faauto\ls2\outlinelevel3\rin0\lin1800\itap0 {\f1\fs20\ul\cf1 D\'e9
jerine-Sottasova hypertrofick\'e1 neuropatia}{\f42\fs20\cf1  \endash  naj\'9da\'9e\'9aia forma, invalidiz\'e1cia u\'9e v detstve
\par {\pntext\pard\plain\s2 \f14\fs30\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs30 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Heredit\'e1rne senzorick\'e9 a auton\'f3mne neuropatie (HSAN)}{\f1\fs20\cf1 :  vz\'e1cnej\'9aie, 15.-20 r., akr\'e1lna porucha citlivosti, ulcer\'e1cie, kostn\'e9 defekty
\par {\pntext\pard\plain\s2 \f14\fs30\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs30 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\ul\cf1 Heredit\'e1
rne neuropatie s tendenciou k tlakov\'fdm par\'e9zam (HNPP)}{\f1\fs20\cf1 : del\'e9cia g\'e9nu PMP22 na 17.chromoz\'f3me, asymptomat.}{\f1\fs20\ul\cf1 
\par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Patogen\'e9za neuropati\'ed
\par Ochorenia perif\'e9rnych nervov
\par {\pntext\pard\plain\s2 \f14\fs36\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs36 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Mononeuropatie}{\f42\fs20\cf1 : postihnutie jedn\'e9ho perif\'e9rneho nervu, naj\'e8astej\'9aie sp\'f4soben\'e1 \'fatlakom vo f}{\f1\fs20\cf1 yziologick\'fdch \'fa\'9ein\'e1ch
\par {\pntext\pard\plain\s2 \f14\fs36\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs36 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\ul\cf1 L\'e9zie plexov}
{\f1\fs20\cf1 : neurapraxia, axonotm\'e9za, neurotm\'e9za
\par {\pntext\pard\plain\s4 \f14\fs26\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs26 {\pntxtb n}}\faauto\ls2\outlinelevel3\rin0\lin1800\itap0 
\fs40\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Plexus cervicalis (C1-C5)}{\f1\fs20\cf1 
\par {\pntext\pard\plain\s4 \f14\fs26\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs26 {\pntxtb n}}\faauto\ls2\outlinelevel3\rin0\lin1800\itap0 {\f1\fs20\ul\cf1 
Plexus brachialis (C4-Th1)}{\f1\fs20\cf1 : horn\'fd typ (Duchenne-Erb)
\par }\pard \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel3\rin0\lin1800\itap0 {\f1\fs20\cf1                                                  doln\'fd typ (Klumpke)
\par }{\f42\fs20\cf1    pr\'ed\'e8iny: traumatick\'e9 par\'e9zy, p\'f4rodn\'e9 par\'e9zy, syndr\'f3my hornej hrudnej apert\'fary \endash  syndr\'f3m kr\'e8n\'e9ho rebra, skalenov\'fd syndr\'f3m, kostoklavikul\'e1rny syndr\'f3m, hyperabduk\'e8n\'fd
 (Wrightov) syndr\'f3m, tumory (Pancoastov tumor)
\par {\pntext\pard\plain\s4 \f14\fs26\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs26 {\pntxtb n}}\faauto\ls2\outlinelevel3\rin0\lin1800\itap0 {\f1\fs20\ul\cf1 
Plexus lumbalis (Th12-L4)
\par {\pntext\pard\plain\s4 \f14\fs26\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls2\pnrnot0\pnf14\pnfs26 {\pntxtb n}}\faauto\ls2\outlinelevel3\rin0\lin1800\itap0 {\f1\fs20\ul\cf1 
Plexus sacralis (L5-S4)
\par {\pntext\pard\plain\s2 \f14\fs36\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs36 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 \'da\'9einov\'e9 syndr\'f3my}{\f42\fs20\cf1 : syndr\'f3m karp\'e1lneho tunelu, sy canalis ulnaris v obl.lak\'9dov\'e9ho k\'e5bu, sy tarz\'e1lneho tunelu}{\f1\fs20\ul\cf1 
\par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Ochorenia perif\'e9rnych nervov
\par {\pntext\pard\plain\s2 \f14\fs30\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs30 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Polyneuropatie}{\f1\fs20\cf1 :  parest\'e9zie a poruchy citlivosti, motorick\'e9 poruchy, vegetat\'edvne poruchy
\par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf1      }{\f1\fs20\ul\cf1 Rozdelenie}{\f1\fs20\cf1 :
\par {\pntext\pard\plain\s4 \f14\fs23\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls4\pnrnot0\pnf14\pnfs23 {\pntxtb n}}\faauto\ls4\outlinelevel3\rin0\lin1800\itap0 
\fs40\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20\ul\cf1 Pod\'bea postihnutia}{\f1\fs20\cf1 :  1. }{\f1\fs20\ul\cf1 senzit\'edvne}{\f1\fs20\cf1  (diabetes, amyloid\'f3za, paraneoplastick\'e9, cirh\'f3zy, otravy th\'e1
liom, cisplatina, vitam\'edn B6); 
\par }\pard \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel3\rin0\lin1800\itap0 {\f1\fs20\cf1    2. }{\f1\fs20\ul\cf1 motorick\'e9}{\f1\fs20\cf1  (otrava olovom, porf\'fdrie, ALS, sy Guillain-Barr\'e9)

\par {\pntext\pard\plain\s4 \f14\fs23\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls4\pnrnot0\pnf14\pnfs23 {\pntxtb n}}\faauto\ls4\outlinelevel3\rin0\lin1800\itap0 {\f42\fs20\ul\cf1 Pod\'be
a klinick\'e9ho priebehu}{\f1\fs20\cf1 : 1. Ak\'fatne (porf\'fdrie, intoxik\'e1cie)
\par }\pard\plain \s6\ql \fi-360\li3240\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel5\rin0\lin3240\itap0 \fs40\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1                                       2. Subak\'fa
tne (alkoholizmus, ur\'e9mia, ca)
\par                                   3. Chronick\'e9 (heredit\'e1rne, syst\'e9mov\'e9 ch.)
\par                                   4. Relapsuj\'face (kolagen\'f3zy, tox\'edny)
\par {\pntext\pard\plain\s4 \f14\fs23\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s4\ql \fi-360\li1800\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls4\pnrnot0\pnf14\pnfs23 {\pntxtb n}}\faauto\ls4\outlinelevel3\rin0\lin1800\itap0 
\fs40\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20\ul\cf1 Pod\'bea pr\'ed\'e8iny}{\f1\fs20\cf1 :      1. Diabetick\'e1 neuropatia
\par }\pard\plain \s5\ql \fi-360\li2520\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel4\rin0\lin2520\itap0 \fs40\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1                             2. Alkoholov\'e1
 polyneuropatia        
\par                           3. Toxick\'e9 polyneuropatie (OF,As,Pb,Th,Hg, 
\par                               nidrazid, cytostatik\'e1, fenytoin, tolu\'e9n)
\par                           4. Paraneoplastick\'e9 polyneuropatie
\par }{\f42\fs20\cf1                           5. Karen\'e8n\'e9 a nutri\'e8n\'e9 polyneuropatie
\par }{\f1\fs20\cf1                           6. Z\'e1palov\'e9 a autoimunitn\'e9 ochorenia
\par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Ochorenia nervosvalov\'e9ho prenosu
\par {\pntext\pard\plain\s2 \f14\fs36\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs36 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Nervosvalov\'e9 spojenie}{\f1\fs20\cf1   je tvoren\'e9 jednoduchou synapsou medzi termin\'e1lnym neur\'f3nom a svalov\'fdm vl\'e1knom \endash  }{\f42\fs20\ul\cf1 nervosvalovou platni
\'e8kou
\par {\pntext\pard\plain\s2 \f14\fs36\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs36 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f42\fs20\cf1 Nervov\'fd impulz 
\endash  Ach \endash  AchR \endash  depolariz\'e1cia \endash  ak\'e8n\'fd potenci\'e1l svalov\'e9ho vl\'e1kna \endash  AchE
\par {\pntext\pard\plain\s2 \f14\fs36\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs36 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf1 
Poruchy: a. postsynaptick\'e9, b. presynaptick\'e9
\par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Ochorenia nervosvalov\'e9ho prenosu
\par {\pntext\pard\plain\s2 \f14\fs36\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls1\pnrnot0\pnf14\pnfs36 {\pntxtb n}}\faauto\ls1\outlinelevel1\rin0\lin540\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Myasthenia gravis}{\f1\fs20\cf1 : autoim\'fanne ochorenie}{\f42\fs20\cf1 , prejavuj\'face sa svalovou \'fanavou a slabos\'9dou kostrov\'e9ho svalstva
\par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf1      }{\f1\fs20\ul\cf1 Prevalencia}{\f42\fs20\cf1 : 10-15/100 000 obyv, \'e8astej\'9aie nad 50 r., mu\'9e
i, alebo diev\'e8at\'e1 a mlad\'9aie \'9eeny
\par }{\f1\fs20\cf1      }{\f42\fs20\ul\cf1 Pr\'ed\'e8ina}{\f1\fs20\cf1 : neobjasnen\'e1; akt\'edvna \'faloha thymu; AchR Ab; genetick\'e1 predispoz\'edcia; \'9apecifick\'e9 Ab proti postsynaptick\'fdm AchR, ktor\'e9 blokuj\'fa prostredn\'edctvom Na-kan\'e1lov

\par      }{\f1\fs20\ul\cf1 Klinick\'fd obraz}{\f42\fs20\cf1 : \'fanava a slabos\'9d po\'e8as d\'f2a, pt\'f3za vie\'e8ok, diplopia, mimick\'e1 par\'e9za, \'9euvacia slabos\'9d, rhinolallia, slabos\'9d pletencov\'fdch svalov
\par }{\f1\fs20\cf1      }{\f1\fs20\ul\cf1 Diagnostick\'fd postup}{\f1\fs20\cf1 : AchR Ab, EMG, SFEMG, CT mediast\'edna
\par      }{\f42\fs20\ul\cf1 Lie\'e8ba}{\f1\fs20\cf1 : thymekt\'f3mia \endash  u mlad\'9a\'edch, inhib\'edtory AchE, imunosupres\'edva, dlhodobe kortikoidy, plazmafer\'e9za, IvIg
\par      }{\f1\fs20\ul\cf1 Progn\'f3za}{\f1\fs20\cf1 : priazniv\'e1
\par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Ochorenia nervosvalov\'e9ho prenosu
\par {\pntext\pard\plain\s2 \f14\fs30\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs30 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Lambert-Eatonov syndr\'f3m}{\f1\fs20\cf1 : autoim\'fanne ochorenie, sp\'f4soben\'e9 protil\'e1tkami proti presynaptick\'fdm kalciov\'fdm kan\'e1lom
\par {\pntext\pard\plain\s3 \f1\fs29\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s3\ql \fi-450\li1170\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls5\pnrnot0\pnf1\pnfs29 {\pntxtb \'95}}\faauto\ls5\outlinelevel2\rin0\lin1170\itap0 
\fs48\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20\cf1 Paraneoplastick\'fd syndr\'f3m \endash  naj\'e8astej\'9aie u malobunkov\'e9ho karcin\'f3mu p\'be\'fac
\par {\pntext\pard\plain\s2 \f14\fs30\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs30 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Kongenit\'e1lne myastenick\'e9 syndr\'f3my}{\f1\fs20\cf1 : heterog\'e9nna, geneticky podmienen\'e1 skupina vz\'e1cnych ochoren\'ed detsk\'e9ho veku, ktor\'e1 nem\'e1 autoimunitn\'fd
 charakter}{\f1\fs20\ul\cf1 
\par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Svalov\'e9 ochorenia
\par {\pntext\pard\plain\s2 \f14\fs30\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard\plain \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs30 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Myopatie}{\f42\fs20\cf1  \endash  spolo\'e8n\'e1 je prim\'e1rna myog\'e9nna l\'e9zia
\par {\pntext\pard\plain\s2 \f14\fs30\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs30 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\ul\cf1 Myopatick\'fd
 syndr\'f3m}{\f42\fs20\cf1  \endash  postihnut\'e9 s\'fa proxim\'e1lne svalov\'e9 skupiny, charakteristick\'e1 je kol\'edsav\'e1 ka\'e8acia ch\'f4dza v hyperlord\'f3ze, obtia\'9ena je najm\'e4 ch\'f4dza do schodov, pacient \'84\'9aplh\'e1\'93
 po vlastnom tele, ke\'ef vst\'e1va z \'beahu, drepu, alebo zo sedu; nesk\'f4r narastaj\'fa svalov\'e9 atrofie, mizn\'fa r\'9ao, IMD kles\'e1; poruchy citlivosti nie s\'fa
\par {\pntext\pard\plain\s2 \f14\fs30\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs30 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\ul\cf1 Diagnostika}{
\f42\fs20\cf1 : EMG, kreat\'ednkin\'e1za, aldol\'e1za, lakt\'e1t dehydrogen\'e1za, myoglob\'edn v s\'e9re a mo\'e8i, svalov\'e1 biopsia, molek}{\f1\fs20\cf1 ul\'e1rna genetika
\par {\pntext\pard\plain\s2 \f14\fs30\cf1 \loch\af14\dbch\af0\hich\f14 \'6e\tab}}\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls3\pnrnot0\pnf14\pnfs30 {\pntxtb n}}\faauto\ls3\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\ul\cf1 Rozdelenie}{
\f1\fs20\cf1 :  1. Geneticky podmienen\'e9 svalov\'e9 dystrofie
\par }\pard \s2\ql \fi-540\li540\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel1\rin0\lin540\itap0 {\f1\fs20\cf1                           2. Kongenit\'e1lne myopatie
\par                           3. Metabolick\'e9 myopatie
\par                           4. Z\'e1palov\'e9 myopatie
\par                           5. Poruchy i\'f3nov\'fdch kan\'e1lov }{\f1\fs20\ul\cf1 
\par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Svalov\'e9 ochorenia
\par Svalov\'e9 dystrofie
\par {\pntext\pard\plain\s2 \f1\fs30\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s2\ql \fi-960\li960\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls6\pnrnot0\pnf1\pnfs30 {\pntxtb \'95}}\faauto\ls6\outlinelevel1\rin0\lin960\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Duchenneova svalov\'e1 dystrofia}{\f42\fs20\cf1 : naj\'e8astej\'9aia forma, RX  (Xp21), postihnut\'ed s\'fa chlapci, prevalencia 20-30/100 000 p\'f4rodov
\par {\pntext\pard\plain\s3 \f1\fs29\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls5\pnrnot0\pnf1\pnfs29 {\pntxtb \'95}}\faauto\ls5\outlinelevel2\rin0\lin1560\itap0 
\fs48\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1         porucha tvorby bielkovinn\'e9ho pr}{\f42\fs20\cf1 oduktu \endash  dystrofin (dystrofinopatie),  ktor\'fd je s\'fa\'e8as\'9dou cytoplazmatickej membr\'e1ny
\par {\pntext\pard\plain\s3 \f1\fs29\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls5\pnrnot0\pnf1\pnfs29 {\pntxtb \'95}}\faauto\ls5\outlinelevel2\rin0\lin1560\itap0 {\f42\fs20\cf1         klinick
\'e1 symptomatol\'f3gia sa manifestuje vo veku 2-5 rokov \endash  slabos\'9d panvov\'e9ho pletenca, myopatick\'e1 ch\'f4dza  a \'9aplh, pseudohypertrofie l\'fdtok, kontrakt\'fary Achillov\'fdch}{\f1\fs20\cf1  \'9aliach
\par {\pntext\pard\plain\s3 \f1\fs29\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls5\pnrnot0\pnf1\pnfs29 {\pntxtb \'95}}\faauto\ls5\outlinelevel2\rin0\lin1560\itap0 {\f42\fs20\cf1 
        medzi 8.-13.rokom s\'fa chlapci na voz\'edku, kyfoskoli\'f3za, flek\'e8n\'e9 kontrakt\'fary
\par {\pntext\pard\plain\s3 \f1\fs29\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls5\pnrnot0\pnf1\pnfs29 {\pntxtb \'95}}\faauto\ls5\outlinelevel2\rin0\lin1560\itap0 {\f1\fs20\cf1 
        medzi 15.-20.rokom s\'fa pacienti celkom imobiln\'ed, kardiomyopatia, dychov\'e1 insufficiencia
\par {\pntext\pard\plain\s3 \f1\fs29\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls5\pnrnot0\pnf1\pnfs29 {\pntxtb \'95}}\faauto\ls5\outlinelevel2\rin0\lin1560\itap0 {\f1\fs20\cf1 
        medzi 20.-30.rokom umieraj\'fa na interkurentn\'fa infekciu
\par {\pntext\pard\plain\s2 \f1\fs30\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s2\ql \fi-960\li960\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls6\pnrnot0\pnf1\pnfs30 {\pntxtb \'95}}\faauto\ls6\outlinelevel1\rin0\lin960\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Beckerova svalov\'e1 dystrofia}{\f1\fs20\cf1 : m\'e1 pomal\'9a\'ed rozvoj o 5-10 rokov
\par }\pard\plain \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel2\rin0\lin1560\itap0 \fs48\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20\cf1         Diagn\'f3za: je pomerne \'beahk\'e1, }{
\f1\fs20\cf1 {\field{\*\fldinst SYMBOL 173 \\f "Symbol" \\s 10}{\fldrslt\f3\fs20}}}{\f1\fs20\cf1  kreatin\'edn, myoglobulin, transamin\'e1zy
\par }{\f42\fs20\cf1                          svalov\'e1 biopsia, t.\'e8. molekul\'e1rna genetika
\par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Svalov\'e9 dystrofie
\par Svalov\'e9 dystrofie
\par {\pntext\pard\plain\s2 \f1\fs36\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s2\ql \fi-960\li960\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls7\pnrnot0\pnf1\pnfs36 {\pntxtb \'95}}\faauto\ls7\outlinelevel1\rin0\lin960\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Facioskapulohumer\'e1lna forma (m.Landouzy-D\'e9jerine)}{\f1\fs20\cf1 
\par {\pntext\pard\plain\s3 \f1\fs32\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls8\pnrnot0\pnf1\pnfs32 {\pntxtb \'95}}\faauto\ls8\outlinelevel2\rin0\lin1560\itap0 
\fs48\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Relat\'edvne ben\'edgnej\'9aie svalov\'e9 ochorenie
\par {\pntext\pard\plain\s3 \f1\fs32\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls8\pnrnot0\pnf1\pnfs32 {\pntxtb \'95}}\faauto\ls8\outlinelevel2\rin0\lin1560\itap0 {\f1\fs20\cf1 
Prevalencia 1-5/100 000 obyv., AD s vysokou penetranciou
\par {\pntext\pard\plain\s3 \f1\fs32\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls8\pnrnot0\pnf1\pnfs32 {\pntxtb \'95}}\faauto\ls8\outlinelevel2\rin0\lin1560\itap0 {\f1\fs20\cf1 G\'e9
n je lokalizovan\'fd na 4.chromoz\'f3me (4q35)
\par {\pntext\pard\plain\s3 \f1\fs32\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls8\pnrnot0\pnf1\pnfs32 {\pntxtb \'95}}\faauto\ls8\outlinelevel2\rin0\lin1560\itap0 {\f42\fs20\cf1 Ochorenie za\'e8
\'edna spravidla medzi 10.-20.r. \'9eivota postihnut\'edm mimick\'e9ho svalstva, ktor\'e9 postupne atrofuje a vystupuj\'fa \'fasta (\'84tap\'edrie \'fasta\'93), pacienti maj\'fa probl\'e9my so zatv\'e1ran\'edm vie\'e8ok, \'9euvan\'edm, nem\'f4\'9eu zap
\'edska\'9d, rozv\'edja sa slabos\'9d pletencov\'e9ho svalstva, oslabenie fix\'e1torov lopatiek
\par {\pntext\pard\plain\s3 \f1\fs32\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls8\pnrnot0\pnf1\pnfs32 {\pntxtb \'95}}\faauto\ls8\outlinelevel2\rin0\lin1560\itap0 {\f1\fs20\cf1 Progresia je pomal
\'e1, priebeh je variabiln\'fd, aj v jednej rodine
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\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Pletencov\'e9 formy
\par {\pntext\pard\plain\s2 \f1\fs36\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s2\ql \fi-960\li960\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls7\pnrnot0\pnf1\pnfs36 {\pntxtb \'95}}\faauto\ls7\outlinelevel1\rin0\lin960\itap0 {\f1\fs20\ul\cf1 
Emery-Dreifussova svalov\'e1 dystrofia}{\f1\fs20\cf1  \endash  vz\'e1cnej\'9aia forma
\par {\pntext\pard\plain\s3 \f1\fs32\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls8\pnrnot0\pnf1\pnfs32 {\pntxtb \'95}}\faauto\ls8\outlinelevel2\rin0\lin1560\itap0 
\fs48\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20\cf1 RX-viazan\'e1 dedi\'e8nos\'9d na dlhom ramienku Xq28, sp\'f4soben\'e1 je deficitom \'9apecifickej bielkoviny emer\'ednu
\par {\pntext\pard\plain\s3 \f1\fs32\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls8\pnrnot0\pnf1\pnfs32 {\pntxtb \'95}}\faauto\ls8\outlinelevel2\rin0\lin1560\itap0 {\f42\fs20\cf1 Za\'e8\'ed
na v detstve, charakteristick\'e9 s\'fa flek\'e8n\'e9 kontrakt\'fary (lakte, Achillove \'9a\'beachy, \'9aijov\'e9 svalstvo, chrbtica, kolen\'e1), kardiomyopatie, poruchy rytmu
\par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Svalov\'e9 dystrofie
\par {\pntext\pard\plain\s2 \f1\fs30\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s2\ql \fi-960\li960\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls6\pnrnot0\pnf1\pnfs30 {\pntxtb \'95}}\faauto\ls6\outlinelevel1\rin0\lin960\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Dist\'e1lne svalov\'e9 dystrofie}{\f1\fs20\cf1  \endash  AD,AR, dist\'e1lne postihnutie
\par {\pntext\pard\plain\s2 \f1\fs30\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s2\ql \fi-960\li960\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls6\pnrnot0\pnf1\pnfs30 {\pntxtb \'95}}\faauto\ls6\outlinelevel1\rin0\lin960\itap0 {\f42\fs20\ul\cf1 O\'e8n\'e9
 myopatie}{\f1\fs20\cf1  \endash  dominuje progreduj\'faca okohybn\'fdch svalov
\par {\pntext\pard\plain\s2 \f1\fs30\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s2\ql \fi-960\li960\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls6\pnrnot0\pnf1\pnfs30 {\pntxtb \'95}}\faauto\ls6\outlinelevel1\rin0\lin960\itap0 {\f1\fs20\ul\cf1 Okulofarynge\'e1
lna dystrofia}{\f1\fs20\cf1  \endash  AD, kombinovan\'e9 postihnutie s pt\'f3zou a progreduj\'facou poruchou hybnosti bulbov a farynge\'e1lnych svalov, s poruchami hltania a dysf\'e1giou
\par {\pntext\pard\plain\s2 \f1\fs30\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s2\ql \fi-960\li960\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls6\pnrnot0\pnf1\pnfs30 {\pntxtb \'95}}\faauto\ls6\outlinelevel1\rin0\lin960\itap0 {\f1\fs20\ul\cf1 Myotonick\'e1
 dystrofia}{\f42\fs20\cf1  \endash  jedno z naj\'e8astej\'9a\'edch nervosvalov\'fdch och}{\f1\fs20\cf1 oren\'ed, prevalencia 13 : 100 000
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\fs48\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Postihnutie je multisyst\'e9mov\'e9, AD, 19q13.3, zmno\'9een\'e9 opakovanie tripletov nukleotidov C-T-G
\par {\pntext\pard\plain\s3 \f1\fs29\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls5\pnrnot0\pnf1\pnfs29 {\pntxtb \'95}}\faauto\ls5\outlinelevel2\rin0\lin1560\itap0 {\f42\fs20\cf1 Klinick\'e9
 prejavy za\'e8\'ednaj\'fa v adolescencii slabos\'9dou dist\'e1lnych kon\'e8atinov\'fdch svalov, \'9aijov\'fdch svalov a m.sternocleidomastoideus
\par {\pntext\pard\plain\s3 \f1\fs29\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls5\pnrnot0\pnf1\pnfs29 {\pntxtb \'95}}\faauto\ls5\outlinelevel2\rin0\lin1560\itap0 {\f42\fs20\cf1 Typick\'e1
 je myotonick\'e1 reakcia s pred\'e5\'9eenou dekontrakciou, IMD je zv\'fd\'9aen\'e1 (poklep na thenar, hypothenar, jazyk)
\par {\pntext\pard\plain\s3 \f1\fs29\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls5\pnrnot0\pnf1\pnfs29 {\pntxtb \'95}}\faauto\ls5\outlinelevel2\rin0\lin1560\itap0 {\f42\fs20\cf1 Intelektov\'fd
 deficit, katarakta, kardiomyopatia, poruchy rytmu, gonad\'e1lna dysfunkcia, thyreopathia, pred\'e8asn\'e1 ple\'9aatos\'9d
\par }\pard\plain \s1\ql \li0\ri0\nowidctlpar{\*\pn \pnlvlcont\ilvl0\ls0\pnrnot0\pndec }\faauto\outlinelevel0\rin0\lin0\itap0 \fs64\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Svalov\'e9 dystrofie
\par {\pntext\pard\plain\s2 \f1\fs30\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s2\ql \fi-960\li960\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls6\pnrnot0\pnf1\pnfs30 {\pntxtb \'95}}\faauto\ls6\outlinelevel1\rin0\lin960\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Kongenit\'e1lne \'9atruktur\'e1lne myopatie}{\f1\fs20\cf1 :
\par {\pntext\pard\plain\s3 \f1\fs29\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls5\pnrnot0\pnf1\pnfs29 {\pntxtb \'95}}\faauto\ls5\outlinelevel2\rin0\lin1560\itap0 
\fs48\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Nemalinov\'e1 myopatia, central core disease, multicore disease, myotubul\'e1rna (centronukle\'e1rna) myopatia
\par {\pntext\pard\plain\s2 \f1\fs30\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s2\ql \fi-960\li960\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls6\pnrnot0\pnf1\pnfs30 {\pntxtb \'95}}\faauto\ls6\outlinelevel1\rin0\lin960\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Metabolick\'e9 myopatie}{\f1\fs20\cf1 :
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\fs48\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Glykogen\'f3zy, deficit karnit\'ednu, mitochondri\'e1lne myopatie, endokrinn\'e9 myopatie, steroidn\'e9 myopatie, toxick\'e9 myopatie
\par {\pntext\pard\plain\s2 \f1\fs30\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s2\ql \fi-960\li960\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls6\pnrnot0\pnf1\pnfs30 {\pntxtb \'95}}\faauto\ls6\outlinelevel1\rin0\lin960\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Z\'e1palov\'e9 myopatie}{\f1\fs20\cf1 :
\par {\pntext\pard\plain\s3 \f1\fs29\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls5\pnrnot0\pnf1\pnfs29 {\pntxtb \'95}}\faauto\ls5\outlinelevel2\rin0\lin1560\itap0 
\fs48\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Polymyozit\'eddy, dermatomyozit\'edda
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\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Poruchy i\'f3nov\'fdch kan\'e1lov}{\f1\fs20\cf1 :
\par {\pntext\pard\plain\s3 \f1\fs29\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s3\ql \fi-840\li1560\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls5\pnrnot0\pnf1\pnfs29 {\pntxtb \'95}}\faauto\ls5\outlinelevel2\rin0\lin1560\itap0 
\fs48\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\cf1 Mal\'edgna hypertermia, periodick\'e9 obrny (hyperK, hypoK, normoK), kongenit\'e1lna paramyot\'f3nia \endash  porucha Na-kan\'e1lov, AD, 17q23.1-25.3, ataky sla}{\f42\fs20\cf1 bosti za
\'e8\'ednaj\'fa v detstve, najm\'e4 v zimn\'fdch mesiacoch
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\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Myotonick\'e9 syndr\'f3my}{\f1\fs20\cf1 :
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\fs48\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f42\fs20\cf1 Kongenit\'e1lna myot\'f3nia \endash  porucha Cl-kan\'e1la, AD (Thomsen), AR (Becker), kulturistick\'fd vzh\'bead; myotonia fluctuans
\par {\pntext\pard\plain\s2 \f1\fs30\cf1 \loch\af1\dbch\af0\hich\f1 \'95\tab}}\pard\plain \s2\ql \fi-960\li960\ri0\nowidctlpar{\*\pn \pnlvlblt\ilvl0\ls6\pnrnot0\pnf1\pnfs30 {\pntxtb \'95}}\faauto\ls6\outlinelevel1\rin0\lin960\itap0 
\fs56\lang1051\langfe1051\cgrid\langnp1051\langfenp1051 {\f1\fs20\ul\cf1 Autoimunitn\'e9 poruchy}{\f1\fs20\cf1 :  neuromyot\'f3nia \endash  paraneoplastick\'e1 
\par }}